Anthony W. Tolcher: search on Z-Library

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1

A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody–drug conjugate, in patients with breast cancer and other advanced solid tumors

Rosen, Lee S., Wesolowski, Robert, Baffa, Raffaele, Liao, Kai-Hsin, Hua, Steven Y., Gibson, Brenda L., Pirie-Shepherd, Steven, Tolcher, Anthony W.

Journal:

Investigational New Drugs

Year:

2019

Language:

english

File:

PDF, 326 KB

english, 2019

2

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors

Weekes, Colin D., Beeram, Muralidhar, Tolcher, Anthony W., Papadopoulos, Kyriakos P., Gore, Lia, Hegde, Priti, Xin, Yan, Yu, Ron, Shih, L. Mason, Xiang, Hong, Brachmann, Rainer K., Patnaik, Amita

Journal:

Investigational New Drugs

Year:

2014

Language:

english

File:

PDF, 387 KB

english, 2014

3

Case report and summary of literature: giant perineal keloids treated with post-excisional radiotherapy

Kristin Jones, Clifton D Fuller, Join Y Luh, Craig C Childs, Alexander R Miller, Anthony W Tolcher, Terence S Herman, Charles R Thomas

Journal:

BMC Dermatology

Year:

2006

Language:

english

File:

PDF, 1.01 MB

english, 2006

4

A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors

Smith, David C., Chugh, Rashmi, Patnaik, Amita, Papadopoulos, Kyriakos P., Wang, Min, Kapoun, Ann M., Xu, Lu, Dupont, Jakob, Stagg, Robert J., Tolcher, Anthony

Journal:

Investigational New Drugs

Year:

2018

Language:

english

File:

PDF, 1.50 MB

english, 2018

5

Phase I and Pharmacologic Study of OSI-774, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Malignancies

Hidalgo, Manuel, Siu, Lillian L., Nemunaitis, John, Rizzo, Jinee, Hammond, Lisa A., Takimoto, Chris, Eckhardt, S. Gail, Tolcher, Anthony, Britten, Carolyn D., Denis, Louis, Ferrante, Karen, Von Hoff,

Journal:

Journal of Clinical Oncology

Year:

2001

File:

PDF, 720 KB

2001

6

Novel apoptosis inducing agents in cancer therapy

Monica Mita, Anthony W. Tolcher

Journal:

Current Problems in Cancer

Year:

2005

Language:

english

File:

PDF, 290 KB

english, 2005

7

A randomized phase 2 trial comparing 3-hour versus 96-hour infusion schedules of paclitaxel for the treatment of metastatic breast cancer

Stacy L. Moulder, Frankie A. Holmes, Anthony W. Tolcher, Peter Thall, Kristine Broglio, Vicente Valero, Aman U. Buzdar, Susan G. Arbuck, Andrew Seidman, Gabriel N. Hortobagyi

Journal:

Year:

2010

Language:

english

File:

PDF, 168 KB

english, 2010

8

A phase II, pharmacokinetic, and biologic study of semaxanib and thalidomide in patients with metastatic melanoma

Monica M. Mita, Eric K. Rowinsky, Leonardo Forero, S. Gail Eckhart, Elzbieta Izbicka, Geoffrey R. Weiss, Muralidhar Beeram, Alain C. Mita, Johann S. de Bono, Anthony W. Tolcher, Lisa A. Hammond, Paul

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 353 KB

english, 2007

9

Preliminary phase I results of G3139 (bcl-2 antisense oligonucleotide) therapy in combination with docetaxel in hormone-refractory prostate cancer

Anthony W Tolcher

Journal:

Seminars in Oncology

Year:

2001

Language:

english

File:

PDF, 425 KB

english, 2001

10

A dose finding, safety and pharmacokinetic study of AVE1642, an anti-insulin-like growth factor-1 receptor (IGF-1R/CD221) monoclonal antibody, administered as a single agent and in combination with docetaxel in patients with advanced solid tumours

Soria, Jean Charles, Massard, Christophe, Lazar, Vladimir, Ozoux, Marie-Laure, Mery-Mignard, Dominique, Deslandes, Antoine, Tolcher, Anthony W.

Journal:

European Journal of Cancer

Year:

2013

Language:

english

File:

PDF, 358 KB

english, 2013

11

Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer

Infante, Jeffrey R., Patnaik, Amita, Verschraegen, Claire F., Olszanski, Anthony J., Shaheen, Montaser, Burris, Howard A., Tolcher, Anthony W., Papadopoulos, Kyriakos P., Beeram, Muralidhar, Hynes, Sc

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 886 KB

english, 2017

12

Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma

Johann S de Bono, Anthony W Tolcher, Eric K Rowinsky

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 840 KB

english, 2003

13

A first-in-human dose-escalation study of the oral proteasome inhibitor oprozomib in patients with advanced solid tumors

Infante, Jeffrey R., Mendelson, David S., Burris, Howard A., Bendell, Johanna C., Tolcher, Anthony W., Gordon, Michael S., Gillenwater, Heidi H., Arastu-Kapur, Shirin, Wong, Hansen L., Papadopoulos, K

Journal:

Investigational New Drugs

Year:

2016

Language:

english

File:

PDF, 521 KB

english, 2016

14

Phase I and pharmacokinetic study of cisplatin and troxacitabine administered intravenously every 28

Chia-Chi Lin, Muralidhar Beeram, Eric K. Rowinsky, Chris H. Takimoto, Chee M. Ng, Charles E. Geyer, Louis J. Denis, Johann S. De Bono, Desiree Hao, Anthony W. Tolcher, Sun-Young Rha, Jacques Jolivet,

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2009

Language:

english

File:

PDF, 444 KB

english, 2009

15

Regulators of apoptosis as anticancer targets

Tolcher, Anthony W

Journal:

Hematology/Oncology Clinics of North America

Year:

2002

Language:

english

File:

PDF, 137 KB

english, 2002

16

Phase II study evaluating the efficacy, safety, and pharmacodynamic correlative study of dual antiangiogenic inhibition using bevacizumab in combination with sorafenib in patients with advanced malignant melanoma

Mahalingam, Devalingam, Malik, Laeeq, Beeram, Muralidhar, Rodon, Jordi, Sankhala, Kamalesh, Mita, Alain, Benjamin, Daniel, Ketchum, Norma, Michalek, Joel, Tolcher, Anthony, Wright, John, Sarantopoulos

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 262 KB

english, 2014

17

Randomized Phase II Study of BR96-Doxorubicin Conjugate in Patients With Metastatic Breast Cancer

Tolcher, Anthony W., Sugarman, Steven, Gelmon, Karen A., Cohen, Roger, Saleh, Mansoor, Isaacs, Claudine, Young, Leslie, Healey, Diane, Onetto, Nicole, Slichenmyer, William

Journal:

Journal of Clinical Oncology

Year:

1999

Language:

english

File:

PDF, 134 KB

english, 1999

18

Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides

Martin E Gleave, Hideaki Miayake, Jim Goldie, Colleen Nelson, Anthony Tolcher

Journal:

Year:

1999

Language:

english

File:

PDF, 733 KB

english, 1999

19

Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors

Mita, Monica, Gordon, Michael, Rosen, Lee, Kapoor, Nirmal, Choy, Gavin, Redkar, Sanjeev, Taverna, Pietro, Oganesian, Aram, Sahai, Amarpal, Azab, Mohammad, Bristow, Robert, Tolcher, Anthony W.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 744 KB

english, 2014

20

Phase I dose-escalation trial of the oral AKT inhibitor uprosertib in combination with the oral MEK1/MEK2 inhibitor trametinib in patients with solid tumors

Tolcher, Anthony W., Kurzrock, Razelle, Valero, Vincente, Gonzalez, Rene, Heist, Rebecca S., Tan, Antoinette R., Means-Powell, Julie, Werner, Theresa L., Becerra, Carlos, Wang, Chenxi, Leonowens, Cath

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2020

File:

PDF, 679 KB

2020

21

Pharmacokinetic behavior of vincristine sulfate following administration of vincristine sulfate liposome injection

Leanne Embree, Karen Gelmon, Anthony Tolcher, Norma Hudon, Jean Heggie, Carole Dedhar, Patricia Logan, Marcel B. Bally, Lawrence D. Mayer

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 314 KB

english, 1998

22

The future of cytotoxic therapy: selective cytotoxicity based on biology is the key

Johann S de Bono, Anthony W Tolcher, Eric K Rowinsky

Journal:

Breast Cancer Research

Year:

2003

Language:

english

File:

PDF, 693 KB

english, 2003

23

A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer

Anthony W. Tolcher, Leonard J. Appleman, Geoffrey I. Shapiro, Alain C. Mita, Frank Cihon, Arthur Mazzu, Pavur R. Sundaresan

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 265 KB

english, 2011

24

A phase 1 study of anti-TGFβ receptor type-II monoclonal antibody LY3022859 in patients with advanced solid tumors

Tolcher, Anthony W., Berlin, Jordan D., Cosaert, Jan, Kauh, John, Chan, Emily, Piha-Paul, Sarina A., Amaya, Alex, Tang, Shande, Driscoll, Kyla, Kimbung, Richard, Kambhampati, S. R. Prasad, Gueorguieva

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2017

Language:

english

File:

PDF, 771 KB

english, 2017

25

Lack of meaningful effect of ridaforolimus on the pharmacokinetics of midazolam in cancer patients: Model prediction and clinical confirmation

Stroh, Mark, Talaty, Jennifer, Sandhu, Punam, McCrea, Jacqueline, Patnaik, Amita, Tolcher, Anthony, Palcza, John, Orford, Keith, Breidinger, Sheila, Narasimhan, Narayana, Panebianco, Deborah, Lush, Ri

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 195 KB

english, 2014

26

Effects of Defined Medium, Fetal Bovine Serum, and Human Serum on Growth and Chemosensitivities of Human Breast Cancer Cells in Primary Culture: Inference for in vitro Assays

Joanne T. Emerman, Eveline E. Fiedler, Anthony W. Tolcher and Patricia M. Rebbeck

Journal:

In Vitro Cellular & Developmental Biology

Year:

1987

Language:

english

File:

PDF, 883 KB

english, 1987

27

Apoptosis: mechanisms and implications for cancer therapeutics

Monica M. Mita, Alain C. Mita, Anthony W. Tolcher

Journal:

Targeted Oncology

Year:

2006

Language:

english

File:

PDF, 432 KB

english, 2006

28

Technology Insight: cytotoxic drug immunoconjugates for cancer therapy

Ricart, Alejandro D, Tolcher, Anthony W

Journal:

Nature Clinical Practice Oncology

Year:

2007

Language:

english

File:

PDF, 354 KB

english, 2007

29

Synergistic chemosensitization and inhibition of progression to androgen independence by antisense Bcl-2 oligodeoxynucleotide and paclitaxel in the LNCaP prostate tumor model

Simon Leung, Hideaki Miyake, Tobias Zellweger, Anthony Tolcher, Martin E. Gleave

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 111 KB

english, 2001

30

Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors

Muhammad Wasif Saif, John Sarantopoulos, Amita Patnaik, Anthony W. Tolcher, Chris Takimoto, Murali Beeram

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2011

Language:

english

File:

PDF, 224 KB

english, 2011

31

First-in-human, open-label dose-escalation and dose-expansion study of the safety, pharmacokinetics, and antitumor effects of an oral ALK inhibitor ASP3026 in patients with advanced solid tumors

Li, Tianhong, LoRusso, Patricia, Maitland, Michael L., Ou, Sai-Hong Ignatius, Bahceci, Erkut, Ball, Howard A., Park, Jung Wook, Yuen, Geoffrey, Tolcher, Anthony

Journal:

Journal of Hematology & Oncology

Year:

2016

Language:

english

File:

PDF, 916 KB

english, 2016

32

Dose determination for molecularly targeted therapies: Much Ado About Nothing

Tolcher, Anthony

Journal:

Year:

2017

Language:

english

File:

PDF, 65 KB

english, 2017

33

O82âA phase 1 dose escalation study of PRS-343, a HER2/4â1BB bispecific molecule, in patients with HER2-positive malignancies

Piha-Paul, Sarina, Bendell, Johanna, Tolcher, Anthony, Hurvitz, Sara, Patnaik, Amita, Shroff, Rachna, Pohlmann, Paula, Zettl, Markus, Hahn, Noah, Krishnamurthy, Anuradha, Duerr, Manuela, Mei, Jian, Av

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2020

File:

PDF, 226 KB

2020

34

Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study

Jordi Rodon, Mitchell Garrison, Lisa A. Hammond, Johann de Bono, Lon Smith, Leonardo Forero, Desirée Hao, Chris Takimoto, John M. Lambert, Lini Pandite, Maria Howard, Hongsheng Xie, Anthony W. Tolcher

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2008

Language:

english

File:

PDF, 377 KB

english, 2008

35

A First‐in‐Human Phase 1 Study of OPB‐111077, a Small‐Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers

Tolcher, Anthony, Flaherty, Keith, Shapiro, Geoffrey I., Berlin, Jordan, Witzig, Thomas, Habermann, Thomas, Bullock, Andrea, Rock, Edwin, Elekes, Agnes, Lin, Chester, Kostic, Dusan, Ohi, Naoto, Rasco,

Journal:

Year:

2018

Language:

english

File:

PDF, 375 KB

english, 2018

36

Analysis of the pharmacodynamic activity of the mTOR inhibitor ridaforolimus (AP23573, MK-8669) in a phase 1 clinical trial

Lori Berk, Monica M. Mita, Jeff Kreisberg, Camille L. Bedrosian, Anthony W. Tolcher, Tim Clackson, Victor M. Rivera

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2012

Language:

english

File:

PDF, 450 KB

english, 2012

37

Pharmacokinetics of SPI-1620 in a Phase I, open label, ascending dose study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the endothelin B receptor agonist, SPI-1620, in recurrent or progressive carcinoma

Reddy, Guru, Tolcher, Anthony, Gulati, Anil, Chawla, Shanta, Allen, Lee F.

Journal:

Year:

2013

Language:

english

File:

PDF, 46 KB

english, 2013

38

Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial

Blay, Jean-Yves, Pápai, Zsuzsanna, Tolcher, Anthony W, Italiano, Antoine, Cupissol, Didier, López-Pousa, Antonio, Chawla, Sant P, Bompas, Emmanuelle, Babovic, Nada, Penel, Nicolas, Isambert, Nicolas,

Journal:

The Lancet Oncology

Year:

2015

Language:

english

File:

PDF, 406 KB

english, 2015

39

Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with erlotinib in patients with advanced solid tumors

Tolcher, Anthony W., LoRusso, Patricia, Arzt, Jennifer, Busman, Todd A., Lian, Guinan, Rudersdorf, Niki S., Vanderwal, Carol Ann, Kirschbrown, Whitney, Holen, Kyle D., Rosen, Lee S.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 467 KB

english, 2015

40

The Evolution of Antibody-Drug Conjugates: A Positive Inflexion Point

Tolcher, Anthony W.

Journal:

American Society of Clinical Oncology Educational Book

Year:

2020

File:

PDF, 469 KB

2020

41

Randomized Phase II Study of BR96-Doxorubicin Conjugate in Patients With Metastatic Breast Cancer

Tolcher, Anthony W., Sugarman, Steven, Gelmon, Karen A., Cohen, Roger, Saleh, Mansoor, Isaacs, Claudine, Young, Leslie, Healey, Diane, Onetto, Nicole, Slichenmyer, William

Journal:

Journal of Clinical Oncology

Year:

1999

File:

PDF, 134 KB

1999

42

A phase I and pharmacokinetic study of the nonpolyglutamatable thymidylate synthase inhibitor ZD9331 plus docetaxel in patients with advanced solid malignancies

Garry H. Schwartz, Christopher B. Jones, Mitchell Garrison, Amita Patnaik, Chris Takimoto, Heather McCreery, Michael Skinner, Anthony W. Tolcher, Eric K. Rowinsky

Journal:

Investigational New Drugs

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

43

Management of High Risk Metastatic Prostate Cancer: The Case for Novel Therapies

Brand, Timothy C., Tolcher, Anthony W.

Journal:

The Journal of Urology

Year:

2006

Language:

english

File:

PDF, 79 KB

english, 2006

44

Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data

Fetterly, Gerald J., Aras, Urvi, Meholick, Patricia D., Takimoto, Chris, Seetharam, Shobha, McIntosh, Thomas, de Bono, Johann S., Sandhu, Shahneen K., Tolcher, Anthony, Davis, Hugh M., Zhou, Honghui,

Journal:

Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.45 MB

english, 2013

45

Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors

Vonderheide, Robert H., Burg, Jennifer M., Mick, Rosemarie, Trosko, Jennifer A., Li, Dongguang, Shaik, M. Naveed, Tolcher, Anthony W., Hamid, Omid

Journal:

Year:

2013

Language:

english

File:

PDF, 1009 KB

english, 2013

46

Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study

Tolcher, Anthony W., LoRusso, Patricia, Arzt, Jennifer, Busman, Todd A., Lian, Guinan, Rudersdorf, Niki S., Vanderwal, Carol Ann, Waring, Jeffrey F., Yang, Jianning, Holen, Kyle D., Rosen, Lee S.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 510 KB

english, 2015

47

Phase I Dose-Finding Study of a New Taxane, RPR 109881A, Administered as a One-Hour Intravenous Infusion Days 1 and 8 to Patients With Advanced Solid Tumors

Gelmon, Karen A., Latreille, Jean, Tolcher, Anthony, Génier, Luc, Fisher, Bryn, Forand, Dominique, D’Aloisio, Susan, Vernillet, Laurent, Daigneault, Luc, Lebecq, Ann, Besenval, Michele, Eisenhauer, El

Journal:

Journal of Clinical Oncology

Year:

2000

Language:

english

File:

PDF, 105 KB

english, 2000

48

A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors

Tolcher, Anthony W., Rodrigueza, Wendi V., Rasco, Drew W., Patnaik, Amita, Papadopoulos, Kyriakos P., Amaya, Alex, Moore, Timothy D., Gaylor, Shari K., Bisgaier, Charles L., Sooch, Mina P., Woolliscro

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2014

Language:

english

File:

PDF, 692 KB

english, 2014

49

A Phase I Dose-Escalation Study of SR271425, an Intravenously Dosed Thioxanthone Analog, Administered Weekly in Patients With Refractory Solid Tumors

Lockhart, A Craig, Calvo, Emiliano, Tolcher, Anthony W., Rowinsky, Eric K., Shackleton, Gareth, Morrison, J Gilmour, Rafi, Rezvan, VerMeulen, Wendy, Rothenberg, Mace L.

Journal:

American Journal of Clinical Oncology

Year:

2009

Language:

english

File:

PDF, 402 KB

english, 2009

50

Phase Ib Study of Utomilumab (PF-05082566), a 4-1BB/CD137 Agonist, in Combination with Pembrolizumab (MK-3475) in Patients with Advanced Solid Tumors

Tolcher, Anthony W, Sznol, Mario, Hu-Lieskovan, Siwen, Papadopoulos, Kyriakos P., Patnaik, Amita, Rasco, Drew, Di Gravio, Donna, Huang, Bo, Gambhire, Dhiraj, Chen, Ying, Thall, Aron, Pathan, Nuzhat, S

Journal:

Clinical Cancer Research

Year:

2017

Language:

english

File:

PDF, 1.56 MB

english, 2017

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